| abstract |
Disclosed are a novel piperidine compound represented by the general formula [I] below which has an excellent tachykinin receptor antagonizing activity and pharmacologically acceptable salts thereof. [I] In the formula, ring A represents an optionally substituted benzene ring; ring B represents an optionally substituted benzene ring; R1 represents an optionally substituted hydroxyl group, a thiol group having a substituent, a sulfonyl group having a substituent, or a group represented by the following formula [II]: wherein R11 represents a carbonyl group having a substituent or a sulfonyl group having a substituent and R12 represents a hydrogen atom or an optionally substituted alkyl group; R2 represents a hydrogen atom or the like; Z represents an oxygen atom or a group represented by -N(R3)- wherein R3 represents an optionally substituted alkyl group or the like; R4a represents an optionally substituted alkyl group; and R4b represents an optionally substituted alkyl group. |