| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e52d2ceaa08506b353a167cfdd83c6e3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_002e254f2647785c2130c0b456f21699
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e9f363b6907cab9a61f8497caf2e2ae1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5408596c12553c12e2c69dab0873f20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_575b9c1356624c28d4b22e3e2ba0809a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-95 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6803 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B15-00 |
| filingDate |
2004-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ab44003a7fd7f5976bf707a7b592a31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4550d5a5f73cf6125815f4c7dc5bf651
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c711642518d78f392bd26c337a0410ff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66ea188e33dcc306994e565ff7ea2d93
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b3798a8c4da17ff2e2690e109832c12 |
| publicationDate |
2005-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2005044087-A2 |
| titleOfInvention |
Methods for the determination of protein three-dimensional structure employing hydrogen exchange analysis to refine computational structure prediction |
| abstract |
The present invention provides methods of structure prediction and/or determination of a protein of interest of unknown structure. Invention methods compare calculated rates of amide hydrogen exchange for a set of predicted possible structures for said protein with experimental hydrogen exchange analysis of said protein to identify valid protein structures based on similarities between hydrogen exchange profiles. In preferred methods, hydrogen exchange analysis is performed by determining the quantity of isotope and/or rate of exchange of peptide amide hydrogen(s) with isotope on a labeled protein, by generating a population of sequence-overlapping endopeptidase fragments of a protein labeled with a hydrogen isotope other than 1H under conditions of slowed hydrogen exchange, and then deconvoluting fragmentation data acquired from said population of sequence-overlapping endopeptidase-generated fragments. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11518607-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101294970-B |
| priorityDate |
2003-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |