http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005042044-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f34119b232d292c72e632b62008eca90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_054cb7facca79e780739e21318bb1a0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3c4feb26742f65f3c9fc21ec998a02ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e623ce40e82aab0041a7b73cfd1efb57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_02bcfedffe5d046559af09eb463ff1ad |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-507 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3687 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-26 |
| filingDate | 2004-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb64fc65c2769bdfe0347315a00c8969 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb679829ccfc59f8f91290dbd7a5e21a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95e19a2e54e3897bcf0c650dbda13c82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e95699d4c25b2f04145e924f10b4605 |
| publicationDate | 2005-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2005042044-A3 |
| titleOfInvention | Bioprosthetic tissue preparation with synthetic hydrogels |
| abstract | Methods for treating xenogenic tissue for implantation into a human body including in-situ polymerization of a hydrogel polymer in tissue, and tissue treated according to those methods, where the polymerization takes place in tissue that has not been fixed with glutaraldehyde. The polymerization may only fill the tissue, bind the polymer to the tissue, or cross-link the tissue through the polymer, depending on the embodiment. One method includes free radical polymerization of a first vinylic compound, and can include cross-linking through use of a second compound having at least two vinyl groups. Another method utilizes nucleophilic addition polymerization of two compounds, one of which can include PEG and can further include hydrolytically degradable regions. In one embodiment, applicants believe the in-situ polymerization inhibits calcification, and that the polymerization of tissue un-fixed by glutaraldehyde allows for improved penetration of the polymer. The methods find one use in the treatment of porcine heart valve tissue, intended to extend the useful life of the valves by inhibiting calcification. The incorporation of degradable hydrogel regions may initially fill the tissue and reduce any initial inflammatory response, but allow for later infiltration by cells to remodel the tissue. |
| priorityDate | 2003-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.