| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc5c5d8e053c56661708694cc94dcb5d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_459618b33efc67c516fffa1a053bb048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9dd175738531c8610326b34fc5884ef9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4b98fbfcca38cb4c5afad7b9814fba29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_73c830a57c1b9c53b9689de953bc07da |
| classificationCPCAdditional |
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-7796
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-5025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-755
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-502715
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0867
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-808
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2400-0655
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-758
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0816
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-752
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-7779
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0654
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-757 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-502746
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-502753
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-5023
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-552 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01L3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-552
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-84 |
| filingDate |
2003-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_672f361e39b5705463cbb862dad9e4de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48ce7332778beaa17ad6b98206f8a8df
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7a520ae82e1ffcfb8232cac7a2d8ad3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9922626361aca2909841ef8be9274822 |
| publicationDate |
2006-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2005041746-A3 |
| titleOfInvention |
Optical sensor and methods for measuring molecular binding interactions |
| abstract |
Methods and devices for the measurement of molecular binding interactions. Preferred embodiments provide real-time measurements of kinetic binding and disassociation of molecules including binding and disassociation of protein molecules with other protein molecules and with other molecules.In preferred embodiments ligands are immobilized within pores of a porous silicon interaction region produced in a silicon substrate, after which analytes suspended in a fluid are flowed over the porous silicon region. Binding reactions occur when analyte molecules duffuse closely enough to the ligands to become bounds. Preferably the binding and subsequent disassociation reactions are observed utilizing a white light source and thin film interference techniques with spectrometers arranged to detect changes in indices of refraction in the region where the binding and disassociation reactions occur. In preferred embodiments both ligands and analytes are delivered by computer controlled robotic fluid flow control techniques to the porous silicon interaction regions through microfluidic flow channels. |
| priorityDate |
2002-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |