abstract |
The invention provides a human GPR1 which is associated with the cardiovascular disorders, dermatological disorders, gastrointestinal and liver diseases, cancer, metabolic diseases, inflammatory diseases, hematological disorders, respiratory Diseases, muscle-skeleton disorders, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, dermatological disorders, gastrointestinal and liver diseases, cancer, metabolic diseases, inflammatory diseases, hematological disorders, respiratory Diseases, muscle-skeleton disorders, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR1 as well as pharmaceutical compositions comprising such compounds. |