| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_455766d0dd911e04dc6a0482e8d83d88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcff13f8573db698307f919e6385d5c4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bf59b349121aba9f6aee94c88306e067 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2842
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- |
| filingDate |
2004-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edaf67c8fd02d6f12aeafb2e73589b44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f799010a3314a9056b494f8d44c16017 |
| publicationDate |
2005-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2005037194-A2 |
| titleOfInvention |
Collagen interactions with prostate cancer cells |
| abstract |
Osteoblastic lesions of the pelvis and vertebral column are the most frequent distant metastases formed in human prostate cancer (CaP). Since Type I collagen comprises 98% of the total protein in bone, the role of collagen binding in to metastatic prostate cancer cells was examined. While bone metastatic bound collagen, non-metastatic prostate cance cells were incapable of collagen binding. Antibodies to both α2β1 integrin and the GRGDTP peptide inhibited this binding, confirming the integrin-mediated attachment. In addition, metastatic prostate cancer cells exhibited an increased ability to migrate towards collagen I, as compared to non-metastatic cells, and α2β1-blocking antibodies prevented this migration. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009018623-A1 |
| priorityDate |
2003-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |