| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_63bd70a2846eedb4505367841ff72fb6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e35c591318c3f7421b93bc2bc33475a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_efdfc7e7bb9f74e4c2cf7801fa9764a5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_28e381f44560e074dfbbd952bc690f5a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d5f2d5f66de30c4025f8d988c29c2e36 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2004-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2adfbd84b27b00c9406ddc98ca93b920
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fd5601ea6ad8057f82ea8daefa7e310
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dde54c5dd1c2f088512a39f2fccfa9f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f598b543bede38d41c2af84916270b22 |
| publicationDate |
2005-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2005035547-A2 |
| titleOfInvention |
E2f oligonucleotide decoy molecules |
| abstract |
The invention concerns E2F oligonucleotide decoy molecules with improved properties. In particular, the invention concerns a double-stranded E2F decoy oligodeoxynucleotide (dsODN) molecule comprising a core sequence that is capable of specific binding to an E2F transcription factor, flanked by 5' and 3' sequences, wherein (i) the core sequence consists of about 5 to 12 base pairs; (ii) the molecule comprises an about 12 to 28 base-pair long double stranded region composed of two fully complementary strands; and (iii) the E217 dsODN binds to said E217 transcription factor with a binding affinity that is at least about 5-fold of the binding affinity of a reference decoy molecule shown in Figure 1 (SEQ ID NOS: 1 and 2), as determined by a competitive gel mobility shift binding assay performed on nuclear extract from THP-1 cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008088301-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008088301-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7482158-B2 |
| priorityDate |
2003-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |