| abstract |
Buccal aerosol sprays or capsules using polar and non-polar solvents have now been developed which provide alprazolam for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprise formulation (I): aqueous polar solvent, alprazolam, and optional flavoring agent; formulation (II): aqueous polar solvent, alprazolam, optionally flavoring agent, and propellant; formulation (III): non-polar solvent, alprazolam, and optional flavoring agent; formulation (IV): non-polar solvent, alprazolam, optional flavoring agent, and propellant; formulation (V): a mixture of a polar solvent and a non-polar solvent, alprazolam, and optional flavoring agent; formulation (VI): a mixture of a polar solvent and a non-polar solvent, alprazolam, optional flavoring agent, and propellant. |