Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_63a4c67a0c9b44a58d74bcf5ddd1c744 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_153f05751ae29550275d192797a48aad http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_607619c6e6cbb044dff2aecf13f9c685 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_686aba57b39c1201bafdd98014b0a386 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3233 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
filingDate |
2004-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2bca5c9ed1a645391e731ae1ea89b061 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5837bc7aae608b693df8dbd3c5392bba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f7562f79febaeb50007122f8ba8424a |
publicationDate |
2005-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2005028617-A2 |
titleOfInvention |
Antisense inhibition of laminin-8 expression to inhibit human gliomas |
abstract |
Using gene array technology, we observed that an increase of the α4 chain- containing Laminin-8 correlated with poor prognosis for patients with brain gliomas. We established that inhibition of Laminin-8 expression by a new generation of highly specific and stable antisense oligonucleotides (MorpholinoTM) against chains of Laminin-8 could slow or stop the spread of glioma. This was demonstrated in an in vitro model using human glioblastoma multiforme cell lines M059K and U-87MG co-cultured with normal human brain microvascular endothelial cells (HBMVEC). Using Western blot analysis and immunohistochemistry, we confirmed that antisense treatment effectively blocked laminin-8 protein synthesis. Antisense oligonucleotides against both α4 and ß1 chains of laminin-8 blocked significantly the invasion of co-cultures through Matrigel. The results show that Laminin-8 may not only contribute to glioma progression and recurrence as part of the neovascularization process but also by directly increasing the invasive potential of tumor cells. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7935677-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3019619-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10383958-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9050373-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013050331-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8911717-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10583151-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9827325-B2 |
priorityDate |
2003-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |