http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005023988-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e680c71ad97a7eca35c98b0196b21917 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e0343d97f01a9239b56ee7c6f0a84fa2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c2352be4a0a0794b45899bdeaa1741c0 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-54 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-066 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-077 |
| filingDate | 2004-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c91e22f285ba20660494e1f833928a15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e648d81ef56858b05e00ab44a1511c91 |
| publicationDate | 2005-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2005023988-A3 |
| titleOfInvention | Modulation of cell intrinsic strain to control matrix synthesis, secretion, organization and remodeling |
| abstract | The present invention provides methods for manipulating the intrinsic strain of cells by treating tissue engineered constructs or native tissue with compounds which affect the intrinsic strain setpoint of the cells in order to modulate matrix synthesis, secretion, organization and/or remodeling so that the tissues withstand in vivo mechanical forces and have the structural characteristics of host tissue which has been permanently altered by injury, atrophy or disease. The compounds include binding site peptides, ATP, UTP and related analogues, IL-1β, TGF-α, cytochalasin D, hyaluronic acid, nocodazole and others. Also providedare methods for applying a mechanical external strain to the tissues, as well as methods for modulating the expression of cytoskeletal genes that transcribe cytoskeletal proteins which regulate a cell's intrinsic strain setpoint. |
| priorityDate | 2003-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.