http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005023982-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4f073eaf5e77768a2f0a3f4ae13f29b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_77b4099386fa15c91567b992f511261c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-193 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-28 |
| filingDate | 2004-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_caecf8512e645a49a10fa1642a81c09a |
| publicationDate | 2005-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2005023982-A2 |
| titleOfInvention | Methods for enhancing engraftment of purified hematopoietic stem cells in allogenic recipients |
| abstract | CD8+/TCR- bone marrow cells facilitate engraftment of hernapoietic stem cells (HSQ in allogeneic recipients without causing graft versus host disease. The present invention identifies the main subpopulation (55-65 %) of CD8+/TCR- facilitating cells (FQ as plasmacytoid precursor dendritic cells (p-preDC). The present invention notably demonstrates that FC and p-preDC share many phenotypic, morphological, and functional features, including IFN-α production, activation and survival after stimulation, and expansion and maturation after FIO-Ligand (FL) treatment. FLmobilized FC, the majority of which express a pre- DC phenotype, facilitate HSC engraftment. Although p-preDC significantly enhance HSC engraftment, they do so with less efficiency than FC. The present invention for the first time defines a direct functional role for p-preDC in HSC engraftment and will have a significant impact on strategies to design effective facilitating cell-based therapies for transplantation. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9452184-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11291686-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2297306-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2297306-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8632768-B2 |
| priorityDate | 2003-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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