| abstract |
A compound represented by the general formula (I): (I) [wherein A is phenyl, etc.; R1 is R1a (R1a is substituted alkyl, etc.), -Z1b-R1b (R1b is substituted alkyl, etc. and Z1b is -NH-, etc.), -Z1c-R1c (R1c has the same meaning as R1b or is alkyl and Z1c is -C≡C-, etc.), -N(R1b)(R1c), etc.; R2 and R3 each is hydrogen, optionally substituted alkyl, OH, etc.; R4 and R5 each is hydrogen, optionally substituted alkyl, OH, etc.; X is OH or alkoxy; and Y is optionally substituted alkyl, etc., provided that when Y is a specific group and A is phenyl, then R4 and R5 each is hydrogen and -C(CF3)2(X) is -C(CF3)2(OH) bonded to the phenyl group in the 3- or 4-position thereof] or a pharmacologically acceptable salt or ester of the compound. They are highly active in bonding to LXR and are useful as a medicine for warm-blooded animals (especially for the human), preferably as a medicine for treatments for and/or prevention of arteriosclerosis, hyperlipemia, inflammatory diseases, diabetes, etc. |