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filingDate 2004-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34d1748ee94b2e6d9efeebc5cae23e93
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publicationDate 2005-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2005021720-A3
titleOfInvention Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
abstract A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1-/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
priorityDate 2003-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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