http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005017122-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c42710c0c64e053bb981f690a1b23520 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_edd8d6e87441cb4385f7ecf018bac0b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_280d87031f0c5786de1808713a1b76b7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54393 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54373 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y30-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y40-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y15-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N- |
| filingDate | 2004-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b9c46cef5872a7679b605aa0aeef4b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e83d61b1172171edb86c26d3cf497d29 |
| publicationDate | 2005-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2005017122-A3 |
| titleOfInvention | Biocompatibile linkers for surface plasmon resonance biosensors |
| abstract | A method of coating an SPR biosensor specific for an analyte to reduce protein fouling, the method has the steps of providing an SPR biosensor, providing a solution of 11-mercaptoundecanol; incubating the SPR biosensor in the 11-mercaptoundecanol solution to form a self-assembling monolayer (SAM); incubating the SPR with SAM in a solution of epichlorohydrin and diglyme; next incubating the SPR in ethanolamine; preparing a solution of EDCNHS and a biocompatible polymer; incubating the SPR from ethanolamine in the EDC/NHS/polymer solution; providing a ligand specific for the analyte in a solution; incubating the polymer-coated SPR in the ligand solution to permit the ligand to react with the polymer-coated SPR; washing the ligand-coated SPR to remove unreacted ligand, thereby providing an SPR capable of reacting with the analyte. Another method replaces the solution for the SAM layer with a solution of MHA or NHS-MHA with HT, and attaches the ligand to the resulting SAM layer. |
| priorityDate | 2003-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.