| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18a1f68bcff8791a36f006e7fbf7470c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d49b7e31b6b0bcd1c8822f85e899e93
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_968b1fc2b5bbec6078c465082071719d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97ef553b22210028bfb9ea8bfe366f29 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-34 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-34 |
| filingDate |
2004-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0f96bf61f9f3788b2a7257acbca7189
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d69462855b51eab7dcd2ff4f21fd4d0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a26e445f598ae67c8824fd06cc3ec37 |
| publicationDate |
2005-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2005014798-A2 |
| titleOfInvention |
Novel compositions and methods for promoting, inhibiting, and detecting protein entry into cells |
| abstract |
In vitro delivery of the diphtheria toxin (DT) catalytic (C) domain from the lumen of purified early endosomes to the external milieu requires the addition of both ATP and a cytosolic translocation factor (CTF) complex. The results presented here demonstrate that both Hsp 90 and TrR-1 activity plays an essential role in the cytosolic release of the C-domain and is mediated by a consensus peptide sequence found on several bacterial toxins and in HIV-1 reverse transcriptase. The invention features methods for inhibiting cell death that include the administration of compounds based on this consensus sequence that inhibit the translocation of the catalytic domain of toxins or transcription factors. Also featured are methods for identifying compounds that inhibit cell death, and methods for identifying compounds that promote cell death by blocking or accelerating, respectively, the rate of toxin/factor endosomal translocation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9170252-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7635484-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8236513-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3217174-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7972801-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014064442-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007126415-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007126415-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7531179-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7855268-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8841253-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7691587-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7968304-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7341843-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7462699-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8137675-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014107718-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7517667-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011133658-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101954073-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7670788-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014107718-A3 |
| priorityDate |
2003-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |