| abstract |
[PROBLEMS] To provide a transdermal absorption preparation with little skin irritation whereby 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide (KRP-197), which is scarcely absorbed via the skin and has antagonism to bladder-selective muscarine receptors M3 and M1, can be continuously and efficiently absorbed into the body via the skin so that a sustained efficacy can be obtained while showing little side effects. [MEANS FOR SOLVING PROBLEMS] A transdermal absorption preparation is formed by flattening, drying or accumulating a composition comprising KRP-197 and an external preparation base to give a transdermal absorption preparation of the pressure-sensitive single layer type or a transdermal absorption preparation of the reservoir type. Thus, a preparation being excellent in the skin permeation of KRP-197 and sustained absorption thereof into the body and showing little skin irritation can be provided. |