http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005010188-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_562e4af016953c0a80e09960559ed0d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f96af624f2606aaef7ccdb9c6fc7b5e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_915351430528647c7a310814778b686a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2330-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate | 2004-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57ccfeb06a06659fad525c43a1cd320a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_adddde5a53378137ce6e9a74aa92b3cf |
| publicationDate | 2005-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2005010188-A3 |
| titleOfInvention | Rnas able to modulate chromatin silencing |
| abstract | This invention generally relates to nucleotide sequences and, in particular, to nucleotide sequences able to bind to or otherwise associate with DNA or chromatin, or otherwise modulate chromatin silencing. In certain embodiments, the nucleotide sequence may be present in (or encode for) a noncoding and/or nonexpressable RNA having less than 50 or 100 nucleotides, preferably about 20-30 nucleotides. In some cases, a precursor nucleic acid may be cleaved in some fashion to produce the nucleotide sequence. In one set of embodiments, the nucleotide sequences of the invention are not native to the cell, i.e., not normally present in the cell. In certain cases, the nucleotide sequence may be a 20-25 nucleotide RNA molecule that occurs naturally in other cells and/or in other organisms, or the nucleotide sequence may be an artificially generated nucleotide sequence, and in such cases, the nucleotide sequence is referred to herein as 'heterochromatic small interfering RNA,' or 'heterochromatic siRNA.' The nucleotide sequences may also be present within a nucleic-acid protein complex in certain embodiments. The nucleotide sequences of the invention may inhibit gene function, for example, by interacting with chromatin, and/or by transcriptionally inhibiting mRNA synthesis. In certain cases, the heterochromatic siRNA of the invention can further posttranscriptionally inhibit gene function, e.g., by binding to mRNA. In some cases, inhibition of the gene may be epigenetic or may otherwise be stable for relatively long periods of time, i.e., chromatin may be epigenetically altered through interaction with the nucleotide sequence, for example, through altered methylation of DNA or histones. |
| priorityDate | 2003-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 19.