| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bedd17ebf078837f5a62aab18e5dd02b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_36afc9a7a991fda247a0bd658f802da8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e0f4f8190960626ec922a1f03bcd4aba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2d3948424e1d4268559b1ba2d6f33d81 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate |
2004-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80462ed4515bb1b382798f715c8c0660
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_506d5ccda3a0508139cba8f9ba4c920f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75e5e9b43fd3cb4abbfcb0b3dac5abe6 |
| publicationDate |
2005-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2005010002-A1 |
| titleOfInvention |
Process for the synthesis of zolpidem |
| abstract |
The present invention relates to processes for the preparation of zolpidem of Formula V as shown in the accompanying drawings or pharmaceutically acceptable salts thereof from N, N-dimethyl-3-(4-methyl) benzoyl propionamide of Formula II. The process includes (a) reacting N,N-dimethyl-3-(4-methyl) benzoyl propionamide of Formula II with bromine to get the bromo amide of Formula III; (b) condensing the bromo amide of Formula III with 2-amino-5-methylpyridine of Formula IV to get the zolpidem base of Formula V; and (c) converting zolpidem base of Formula V to its hemitartarate salt of Formula VII. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101198327-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1883408-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1883408-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006008636-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006008636-A3 |
| priorityDate |
2003-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |