| abstract |
Aryl-substituted benzo[d]isothiazol-3-ylamine analogues are provided, of the Formula (I): wherein variables are as described herein. Such compounds are ligands that may be used to modulate capsaicin in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological capsaicin receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies. |