| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_29aff3a587685963731410e344347c51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_30c6cc2ae836d9df311b1954dddc469f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e5fa1849a161d635b881706c5f40704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_adb0e564374fedf34b36103d36e6455a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cdde179f29538e5d5e7beafeedeeb2a9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_caf1960b48be555e2943685d0953ca02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-00 |
| filingDate |
2004-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38e36ace9f6fe77a253bdf0373f4bf1e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afdb20032d14811b037bd4340a1843a2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67622ac9cf2002678426b2651f94ddc3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30b36a62c76317148bed6e2b1fb219d7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49cc11caa38df05b46b1a4d95ebf4f53 |
| publicationDate |
2005-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2005003367-A2 |
| titleOfInvention |
Process for the preparation of cephradine |
| abstract |
The present invention describes a process for preparing cephradine, said process comprising reacting 7-aminodesacetoxy cephalosporanic acid (7-ADCA) with D-dihydrophenylglycine in activated form (DHa) in the presence of an enzyme in a reaction mixture to form cephradine, resulting in a conversion of 7-ADCA into cephradine of at least 70 %, wherein the concentration D-dihydrophenylglycine (DH) in the reaction mixture is below 2 wt.%, wherein the conversion of 7-ADCA into cephradine = (nCEF/ n7-ADCA) *100%, wherein nCEF=quantity of cephradine formed (in mole); and n7-ADCA =total quantity of 7-ADCAadded to reaction mixture (in mole). The invention also describes a process for the preparation of cephradine hydrate characterised in that the process comprises: - reacting 7-amino acid desacetoxy cephalosporanic acid (7-ADCA) with DHa in the presence of an enzyme in a reaction mixture to form cephradine; - preparing an aqueous solution comprising at least part of the cephradine; and crystallising the cephradine from said aqueous solution. The invention further describes cephradine hydrate obtainable by a process according to invention. The invention also describes cephradine hydrate with an absorbance at 450 nm of below 0.050. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011073166-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103667418-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011073166-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010072765-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8541199-B2 |
| priorityDate |
2003-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |