| abstract |
The present invention relates to metabolites of tricyclic amides, and structurally related compounds, represented by the structural formula (I) and pharmaceutically acceptable isomers, salts, solvates or esters of the compound of formula (I), wherein: R1 is selected from the group consisting of H and =O; R2-R5 can be the same or different, each being independently selected from the group consisting of H, -OH, halide, -NH2 and =O; and, the combination solid-dashed lines independently represent either single bonds or double bonds, wherein the number of combination solid-dashed lines that are double bonds is not greater than 2, and when 2, the double bonds are not adjacent, and when 0, one of R1-R5 is not H. Also disclosed are methods of treatment of proliferative diseases and methods for inhibiting the abnormal growth of cells, and for inhibiting farnesyl protein transferase using the novel compounds. |