| abstract |
A drug which is effective in treatments for and prevention of psychiatrical disorders and in treatments for and prevention of neurological diseases. The drug has an antagonistic effect on a Group II metabotropic glutamate receptor. It is a 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative represented by the formula [I]: [I] (wherein R1 and R2 are the same or different and each represents hydrogen, C1-10 alkyl, etc.; X represents hydrogen or fluorine; and Y represents amino, -SR3, -S(O)nR7, -SCHR3R4, -S(O)nCHR3R4, -NHCHR3R4, -N(CHR3R4)(CHR5R6), -NHCOR3, or -OCOR7), a pharmaceutically acceptable salt of the derivative, a hydrate of either, etc. |