| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_95cb1da691a7ea419bcb8ab89ee37319
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5fb75f9da308b3cd588ca985236675dc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a01d7935508cbe002beb151d4efde669
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_58fae6ed39629347af9a545147f463b7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_09eed46a85680120a85d62fd1013ffbc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_decb9d8d68eb5b81968b112dfc85a69d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3fa3fb2d54bec2b5bb3e64c44d4fb082
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cdb2da206073beaf17d04ef79f1fe9a2 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39541
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-195
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-425
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate |
2004-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0ee1220807df551dfe1497979164462
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31cdac7b067b5f1c17a9ce96a0f575a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2cf6421b43d17246a31942effd35a95b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34838208867c72f7c0b6d61435560a33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bfc4228013f5439d8277e1e82c77c43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4067b4eb21df43e0c99646ecfe3eae64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6157ba5f66bac134f01380eb2497981 |
| publicationDate |
2005-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2005000246-A3 |
| titleOfInvention |
Methods and compositions for treating rheumatoid arthritis |
| abstract |
This application relates to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and an antibody to alpha 4 integrin or an immunologically active antigen binding fragment in therapeutically effective amounts. The application also relates generally to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and small molecule alpha-4 integrin antagonist that inhibits the alpha-4 integrin ( 4 integrin) interaction with VCAM-1. The invention further relates to methods of preparing the compounds and methods of using the compounds and compositions. |
| priorityDate |
2003-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |