| abstract |
A device for controlled delivery of biologically active agent into a liquid environment comprises an extruded cylindrical core (1) of matrix material in which the agent is dispersed, which either has several lumens (5, 6) extending generally axially between the two ends (3, 4) or has one lumen extending between the two ends, but spaced from the axis of the core, where the core is erodible. The external cylindrical wall (2) may have an insoluble and impermeable coating, whereby release of active agent takes place only by passage of liquid through the lumen(s). Selection of the diameter and length of the lumens and of the matrix material and any coatings allows for control of the release rate of the agent. The device is of particular utility as an orally administrable drug delivery device. |