| abstract |
[PROBLEMS] To provide a preventive or a remedy for a disease associated with apoptosis such as myocardial infarction, brain infarction, hepatitis or ischemic reperfusion injury in heart, lung, liver, small intestine, pancreas or kidney. [MEANS FOR SOLVING PROBLEMS] By administering modified Bcl-xL in which asparagine residues at the 52- and 66-positions of an antiapoptosis substance Bcl-xL have been substituted both into alanine or expressing the same in a cell, a disease associated with apoptosis such as myocardial infarction, brain infarction, hepatitis or ischemic reperfusion injury in heart, lung, liver, small intestine, pancreas or kidney is treated. |