| abstract |
The invention provides a human PRSS8 which is associated with the cardiovascular diseases, dermatological disorders, endocrine system and hormone disorders, cancer disorders, metabolic diseases, inflammatory diseases, gastrointestinal and liver diseases, respiratory diseases and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological disorders, endocrine system and hormone disorders, cancer disorders, metabolic diseases, inflammatory diseases, gastrointestinal and liver diseases, respiratory diseases and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of PRSS8 as well as pharmaceutical compositions comprising such compounds. |