| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4750d99e2c1f6f04d2e47f779d13bf03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6fc5201f01f29f9846d6c03ee598ebc9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_548192860294ffc2aac43314f184a7f5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df1df309a415a9465769bee7a687b213
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba424cfc324c087e5e0782f9be3823be
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2fcdc57c48a32747ab036792c451560c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-004 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-62 |
| filingDate |
2004-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_862b0054f2d395a2ba625e27b41773bb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fb0ff0663304f0d02aec147ad73c791
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_579ea535b5d126cddb087202366f1e73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_411d90589d18c77b33c662672613ae37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e57f4b77e644d3bc37a10261e1563bac |
| publicationDate |
2005-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2004106534-B1 |
| titleOfInvention |
The enzymatic method of making 1,2-diol derivatives and their esters with succine anhydride |
| abstract |
The present invention relates to a new process for the preparation of optically active alcohols represented by the general formula 2 and their esters represented by the general formula 3 in scheme 1. In more detail, this invention relates to the process for the preparation of optically active alcohols and their esters which are used as pharmaceutical intermediates by reacting the hydroxyl group stereospecifically by lipase after adding racemic alcohols represented by the general formula 1 and succinic anhydride as an acylating agent to the organic solvent. According to this invention, the primary hydroxyl group of 1,2-diols is transformed by other functional group and the secondary hydroxyl group is esterified stereospecifically with succinic anhydride as an acylating agent. Optically active alcohols and their esters of high optical purity in high yield can be produced by using succinic anhydride as an acylating agent because alcohols can be separated from their esters more easily than those of other conventional methods. |
| priorityDate |
2003-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |