| abstract |
The invention provides a human IGS70 which is associated with the cardiovascular disorders, dermatological disorders, endocrine system and hon-none disorders, inflammatory diseases, gastrointestinal and liver diseases, hernatological disorders, respiratory diseases, neurological disorders, metabolic diseases and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, dermatological disorders, endocrine system and hormone disorders, inflammatory diseases, gastrointestinal and liver diseases, hematological disorders, respiratory diseases, neurological disorders, metabolic diseases and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of IGS70 as well as pharmaceutical compositions comprising such compounds. |