| abstract |
An immunocompetent cell activation inhibitor comprising an antibody against OPN or fragment peptide portion thereof; a therapeutic agent for diseases attributed to immunocompetent cell activation, comprising this inhibitor as an active ingredient; and a method of treatment with the use of the therapeutic agent. Thus, there can be provided a medical agent capable of treating diseases attributed to immunocompetent cell activation, such as hepatopathy, spasmodic asthma, articular inflammation, diabetes, lupus, insular sclerosis, arteriosclerosis and lung fibrosis, etc. |