| abstract |
The present invention relates to improved pharmaceutical preparations containing substituted benzimidazoles,(i.e.omeprazole, lansoprazole, pantoprazole, and rabeprazole). The preparations comprise an inert core, constituted by starch and sugar, surrounded by active coating containing at least one substituted benzimidazole in the micronized form, which is mixed with pharmaceutically acceptable non-alkaline and inert excipients, followed by intermediate coating and an enteric coating, in order to guarantee the integrity of the product until it reaches the proximal part of the small intestine, where the formulation will be disaggregated to facilitate the absorption of the substituted benzimidazole compound. |