| abstract |
This invention relates to novel procolipase-like polynucleotides, polypeptides and antibodies. The invention also describes the related procolipase variants. Disclosed herein are the use of the novel procolipase-like polynucleotides, polypeptides and antibodies and their variants in the methods of treating overweight, obesity, dislipidemia and cardiovascular diseases. Also described herein are the uses of the polypeptide as a therapeutic with a combined effect of lipase inhibition and appetite suppression. |