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filingDate 2004-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2004-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2004089404-A1
titleOfInvention Hemoglobin conjugate and the preparation method and its use
abstract Present invention provides a hemoglobin and human serum albumin conjugate and its preparation. The conjugates has Mr of between 100-300KD, comprising 1-3 hemoglobin molecules crosslinked intermolecularly or intramolecularly and 1-3 human serum albumin molecules, which gained by following steps: prepared stroma-free hemoglobin, then coupled hemoglobin to human serum albumin and purified products using anion exchange chromatography. The protein conjugate have good characteristic using as a blood substitute.
priorityDate 2003-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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