| abstract |
The present invention relates to pharmaceutical compositions, and processes for their preparation, for oral administration that provides a colon specific delivery. The pharmaceutical has a coating having thickness less than 60 µm. The pharmaceutical composition is in the form of single dosage unit for selectively administering to the colon an active agent or its pharmaceutically acceptable salt or ester thereof. The pharmaceutical composition includes a core and a coating. The core includes an active agent or its pharmaceutically acceptable salt or ester thereof. The coating includes a layer of an anionic copolymer of methacrylic acid and methacrylic methyl ester in which the ratio of free carboxyl to ester group is about 1:2. The active agents that can be used include prednisolone, indomethacin, ibuprofen, mesalamine and the like. |