| abstract |
A method for the treatment of leishmaniasis, comprising administering a therapeutically effective amount of a compound of Formula I wherein R1, R2, R4 and R5 are H, OH, OR6, or R1 and R2 and/or R4 and R5 together forming a methylenedioxy or other bridging group of the form -O-(CH2)n-O- where n is 1, 2 or 3, where R6 is a carbohydrate residue, phosphate residue, sulfate residue or lower alkyl, and R3 is H or lower alkyl. Lower alkyl may be a linear, branched or cyclic group having less than about 6-10 carbons, optionally including one or more single or double bonds. The method also includes admnistering a pharmaceutically acceptable salt of a compound of Formula I and administration of a pharmaceutical composition containing a compound of Formula I together with one or more pharmaceutically acceptable ingredients. |