| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_01a96e8bbea00eeaa0b50c2a0c000dba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61280b01d51e65efce2aa1d11db10880
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da3081d1302c1062737f43b7152bc380
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6d9cfaa00c311041d638e0b52383fdb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a3f4ac681ebbaf7453aadbf52e971b2 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T428-31848 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G73-0206
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F283-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F283-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F271-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G83-003 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F8-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F285-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-785
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-74 |
| filingDate |
2004-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5aa1d41e844676641914ef5b236323be
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d018ab0afae9cc26575e72dcb18b388f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f50e17112bdadc361b2a55ac37ebcb6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eea1e7733b3dbb587f4549e717dc3582 |
| publicationDate |
2005-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2004083450-A3 |
| titleOfInvention |
Hyperbranched dendron and methods of synthesis and use thereof |
| abstract |
Hyperbranched dendron (HD) polymers are synthesized using low molecular weight polyethyleneimine (BPEI-L) as a core and used for gene delivery. The obtained polymers display low toxicity and efficient gene delivery at low nitrogen-to-phosphate (N/P) ratios. Using successive attachment of ethyleneimine moieties to a PEI core, the polymer has a lower relative ratio of linear-to-branched structures than in the core PEI. The more extensive branching enables the polymer to condense plasmid DNA into nanostructure complexes with a size of less than or equal to about 100 nm. The complexes are stable and efficient in transfecting cells in the presence of serum. Bioluminescent imaging of in vivo gene expression using a luciferase reporter gene performed in live mice showed gene expression in the liver and in submandibular lymph nodes. |
| priorityDate |
2003-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |