| abstract |
The invention relates to the use of nitrogeneous polycyclic derivatives for preparing drugs for treating neurodegenerative diseases, said derivatives having formula : (I) wherein Rn is R1, R2, R3 and R4, identical or different and represent H or one or several radicals selected in the group comprising -OH, alkyl, -O-alkyl, -NH2, -NH-alkyl, -N (R5, R6), the alkyl being a C1-C6 alkyl, or an halogen, - Y forms a phenyl with both pyridines, optionally ortho-substituted by R5, or ortho-disubstituted by R5 and R6, said substitutuents, identical or different, being selected amongst alkyl, -O-alkyl, -NH2, -NH-alkyl, -N (R5, R6), the alkyl being a C1-C6 alkyl, or an halogen, or represents -(CH2) ml-W-(CH2)ml, with M1 and M2 being 0, 1 or 2, and W being a group -CH2-, -CH-(R7), 0, or N (R8, R9), R7, R8 and R9, identical or different, being a C1-C3 alkyl radical, or H, - Z is -A-(CH2)m-U-(CH2)n -A-, with A = O or N, and U = -(CH2)n -, -N(R1, R2), -COOH, -OH, with n is 2 to 6, and n1 is 0 or 1, and the complexes thereof with transition metals. |