http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004081191-A2

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filingDate 2004-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a51e7360c3c1139985318dbbb72025ad
publicationDate 2004-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2004081191-A2
titleOfInvention Molecular haplotyping of genomic dna
abstract A method of determining the haplotype structures of a nucleic acid comprising two or more single nucleotide polymorphisms (SNPs) of interest is provided. The method comprises: obtaining an enriched nucleic acid fraction which comprises from 2 to 30 times more of one allelic variant of the nucleic acid than the other allelic variant of the nucleic acid; and genotyping the enriched nucleic acid fraction to identify the alleles in the two or more SNPs of interest that are present at a higher level or lower level than the other alleles in said two or more SNPs of interest, wherein the alleles that are present at a higher level are on the enriched allelic variant and form one haplotype and the alleles that are present at a lower level are on the non-enriched allelic variant and form the other haplotype. Kits for conducting the present methods are also provided.
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