| abstract |
The invention relates to cells from a stable cell line, e. g. monoclonal, having at least one inactive X chromosome, expressing a fusion protein comprising a protein which is associated with heterochromatin, such as a histone variant, and a fluorescent protein. The invention also relates to a method of preparing the stable cell line and to the use of said stable cell line cells for the screening of agents that can modify the texture of the chromatin and, in particular, the inactive state of the inactive X chromosome. |