| abstract |
A prostaglandin derivative represented by the following general formula [I], its pharmaceutically acceptable salt or a hydrate thereof which has an excellent antagonism to prostaglandin DP receptor and, therefore, is useful against diseases such as allergic rhinitis, nasal obstruction, asthma, allergic conjunctivitis, systemic mastocytosis and systemic mast cell disease; [I] wherein X represents halogeno; Y represents ethylene, vinylene or ethynylene; Z represents -(CH2)m-, -O(CH2)n- or -S(O)p-(CH2)n- (wherein m is an integer of from 0 to 3; n is an integer of from 0 to 2; and p is an integer of from 0 to 2); R1 represents hydrogen or optionally substituted C1-5 alkyl; R2 represents C3-10 cycloalkyl optionally substituted by C1-4 alkyl or C4-15 cycloalkyl; and R3 represents hydrogen, halogeno or optionally substituted C1-5 alkyl. |