| abstract |
Novel azetidine-derived inhibitors of dipeptidyl peptidase IV (DPP IV), pharmaceutical compositions comprising therapeutically effective amounts of such inhibitors, and novel methods of treating medical conditions are provided. The novel DPP IV inhibitors described herein feature an azetidine ring substituted with one or more groups selected from fluoro-, di-fluoro, oxo-, cyano, alkoxy, and alkyl, and are useful in the treatment of neurological disorders, mental illness, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, and of such other medical conditions as can be treated with inhibitors of DPP IV. |