| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50242ec885fe92bc87f60166c56b25de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_504cc90e6acda926126c97837d15629d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_83e222ae44f63b1e34f4c9c0cc61e61c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47efab9bd0644333d5fb98120810d91e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ce6cb23b481f1a33da343841c43ebe16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cc8133ee6f7033a7aebf397dcb23ad34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7162bb34b8383525ee0a3fe4e8e06b0c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f199366028c78706cd9a3a7c5f28f476 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-975
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-205 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-20 |
| filingDate |
2003-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bd9a4316b42b450da505a7f2c344498
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd5394cbb46eb31585d643b6f29becb7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d74bf581bcaf6e2b9cdf3da7b6748df2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd076f38f670e971dbf323d2b9846fd6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d4eee3f2c34ae2a814320f54392117e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3270facabccb2f0532f51b98adb064f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f95d34c3a080382e25ceaf322d87970 |
| publicationDate |
2004-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2004067559-A1 |
| titleOfInvention |
Compounds useful in the diagnosis and treatment of pregnancy-associated malaria |
| abstract |
The present invention relates to nucleic acid molecules related to the var2csa gene family as well as amino acid sequences encoded by such nucleic acid molecules with respect to their role in mediating adhesion of infected red blood cells to chondroitin sulphate A (CSA) in the placenta which is characteristic for the pathogenesis of pregnancy associated malaria (PAM). Accordingly, The invention provides the use compounds that are related to VAR2CSA polypeptides and var2csa nucleic acid molecules as medicaments, as well as it provides pharmaceutical compositions, in particular immunological compositions and vaccines, hereunder nucleotide-based vaccines comprising these compounds. In addition, the invention provides the use of the compounds mentionedfor the manufacture of compositions, such as immunogenic compositions. Other aspects of the invention relates to methods of treatment and prevention of pregnancy associated malaria wherein these methods are based on the nucleic acid molecules and polypeptides of the invention. As these compounds can also be used as biotechnological tools the invention provides in vitro diagnostic methods and kits comprising reagents and IgGs/antibodies designated to the use in such methods. The invention also relates to methods of identifying agents capable of modulating the VAR2CSA dependent adhesion to CSA and agent capable of interacting with VAR2CSA. Finally, a method for identifying polypeptides, which will induce a specific IgG/antibody response upon administration to a subject is provided by the invention. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9926350-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012014073-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AP-4023-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-031876-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013117705-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11787844-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2963241-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9540425-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104136041-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9932375-B2 |
| priorityDate |
2003-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |