| abstract |
This invention relates to novel compounds, which bind to tissue factor and the use thereof for diagnostic markers. The invention also relates to pharmaceutical compositions comprising the novel compounds as well as their use in the diagnosing, prophylaxis or treatment of diseases or disorders relates to pathobiology involving tissue factor (TF) including bleedings, cancer, inflammation, atherosclerosis and ischemia/reperfusion. Radiolabelled TF agonists may be valuable for diagnostic imaging with a gamma camera, a PET camera or a PET/CT camera, in particular for the evaluation of TF expression of tumor cells, for grading the malignancy of tumor cells known to express TF receptors, for the monitoring of tumors with TF expression during conventional chemotherapy or radiation therapy. Also TF agonists and/or TF antagonists labelled with alpha or beta-emitting isotopes could be used for therapy, possibly with bi-specific binding to compounds with chemotherapeutic action, which may be related tp the presence of TF receptors. |