| abstract |
A multi-layer oral dosage form, preferably a tablet, comprising a matrix core comprising a therapeutically effective amount of a first drug (NSAID), wherein the matrix core allows sustained release of the first drug; a first layer, which is in contact with the matrix core, comprising a first portion of a pharmaceutically effective amount of a second drug (H2-blocker antagonist) , wherein the first layer allows sustained release of the second drug; and a second layer, which is in contact with said matrix core, comprising a second portion of the second drug, wherein the second layer allows immediate release of the second drug. Methods for preparing the multi-layer dosage form are also disclosed. |