| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb5a41c841d28374754ef6be035d40f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7fb4db3f181c764ccee636bcc1dae622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e72837de81999e7e72cb78d59d19e28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_28b2a292b4292fa07f7e7f29a68b9e36 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L101-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J3-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G73-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G63-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G73-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F261-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-765
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L71-00 |
| filingDate |
2004-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_697534a1a9047c8acddabe754bde83b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f0352be9b46314a29efebe86df2d253
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97218a333ea23c4ade61ab1225be3281 |
| publicationDate |
2005-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2004063388-A3 |
| titleOfInvention |
Hydroxyphenyl cross-linked macromolecular network and applications thereof |
| abstract |
A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, such as artificial or synthetic cartilage. The network is made by first providing a polyamine or polycarboxylate macromolecule (having a plurality of amine or carboxylic acid groups respectively attached along the length of the molecule), reacting this macromolecule with a hydroxyphenyl compound having a free carboxylic acid group in the case of a polyamine or a free primary amine group in the case of a polycarboxylate, and substituting the hydroxyphenyl compound onto the macromolecule via a carbodiimide-mediated reaction pathway to provide a hydroxyphenyl-substituted macromolecule. This macromolecule is then linked to other such macromolecules via an enzyme catalyzed dimerization reaction between two hydroxyphenyl groups attached respectively to different macromolecules under metabolic conditions of temperature and pH. In a preferred embodiment, the macromolecular network is made up of tyramine-substituted hyaluronan molecules that are linked by dityramine bonds to provide a stable, coherent hydrogel with desired physical properties. A method of preparing such a network is also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8034362-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7985781-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8262730-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8017107-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8062739-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7947784-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7731988-B2 |
| priorityDate |
2003-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |