| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9ebf8144fa4bcdf1fcd3be144d9aae99
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bbce806052b0cecb37e98f8ff46daf3c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc2cb70aa8d3e6a8f976be09e80e0154
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b22a40e04fd09670c076eb2d9cd09515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fcf5f8862c47d9c32ad47dc452711592
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bf8f324bf8e22ef1afc98fbc11f8ab16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_62932b83fa6115f9b57cd9565130e9de |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-18 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-18 |
| filingDate |
2003-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d56504bbc803ac23dca4f6492b4a02aa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a31aee99d913faa0b676698d206b82d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b8d0304cbb249218e55e19c52d31fb3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b079a3150e6baf011812ac168d630d9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc26faa0366fcf6d1d47302137250a8e |
| publicationDate |
2004-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2004063170-A1 |
| titleOfInvention |
A process for the synthesis of bisbenzimidazoles and its derivations |
| abstract |
A process for the synthesis of bisbenzimidazoles and its derivations comprising; (i) reacting 5 chloroaniline with zinc dust and acetic anhydride to produce 5 chloroacetanilide; (ii) reacting 5 chloroacetanilide with HN03 to produce 2-nitro-5-chloroacetanilide; (ix) adding sodium methoxide to 2-nitro-5-ch1oroaniline; (x) heating 2-nitro-5-chloroaniline, methyl piperazine, anhydrous K2CO3 and Dimethyl formamide at 100-120°C produce a mixture which is cooled by pouring ice and is filtered to obtain 5-(4'-methylpiperazin-1'-yl)-2-nitroaniline; (xi) treating 5-(4'-methylpiperazin-l'yl)-2-nitroaniline with Pd/C to produce 2-amino-4-(4'-methylpiperazin-1'-yl) aniline; (xii) refluxing a mixture of 2-amino-4-(4'-methylpiperazin-1'yl) aniline and ethyl-4-amino-3-nitrobenzenecarboximidate hydrochloride in presence of ethanol/glacial acetic acid to produce 4-[5'-(4'-methylpiperazin-1'-yl) 15 benzimidazol-2'-yl)-2-nitroaniline; (xiii) treating a solution of 4-[5'-(4'-methylpiperazin-1'-yi) benzimidazol-2'-yl)-2-nitroaniline with palladium on carbon to yield 2-amino-4-[5'-(4'-Methylpiperazin-1'-yl)benzimidazol-2'-yl]aniline; (xiv) heating 2-amino-4-[5'-(4'-Methylpiperazin-1'-yl)benzimidazol-2'-yl]aniline and 3-4-dimethoxy benzaldehyde using nitrobenzene as a solvent at 110-150°C to produce (DMA) i.e 5-(4-methylpiperazin-1-yl)-2-[2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl] benzimidazole; (ix) heating 2-amino-4-[5'-(4'-Methylpiperazin-1'-yl) benzimidazol-2'-YI] aniline and 5-Formyl-[3-methoxy-4-hydroxy benzimidazole] using nitrobenzene at 110°C to 150°C in presence of argon to produce (TBZ) i.e 5-(4-methylpiperazine-1-yl)-2-[2' (2'-(4-hydroxy-3methoxyphenyl)5'benzimidazolyl) -5'- benzimidazolyl] benzimidazole. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7838527-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2465857-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8999993-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102933557-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103506133-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112858459-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014012682-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112858459-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011123890-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101324863-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE46943-E
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8222413-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006213674-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7335774-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008540675-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006125130-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102933557-B |
| priorityDate |
2003-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |