| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f74ab5be251cd9cd1f482cc1e324e7f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_797a31579e8e262c046bffa6806c8fd7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc5347501d662d16e805a190886e1eac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7451578e314a1cb67adde7facad8fda0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2035-126
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-48 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0619 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0793 |
| filingDate |
2004-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06b49799d3b806e227fa300bb7617984
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff37c5a4804744454c73f85acc09bbc8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70143f4d67e18429b986f61569836e52 |
| publicationDate |
2004-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2004062554-A2 |
| titleOfInvention |
Enhancement of dopaminergic neuron generation and survital |
| abstract |
The present invention concerns methods for enhancing the survival of neurons and especially tyrosine hydroxylase expressing neurons and dopaminergic neurons. The invention is based on the finding that Bcl-XL enhances the survival of neurons and specifically enhances the survival of TH+ and dopaminergic neurons. The present invention provides a method for producing Bcl-XL overexpressing neural cell lines expandable in vitro for cell banking. Such a cell line is able to efficiently differentiate into cells with a neuronal phenotype similar to the nigral dopaminergic neurons. Furthermore, the cells are able to survive, maintain their dopaminergic phenotype and function following transplantation and integration into the striatum. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021183674-A1 |
| priorityDate |
2003-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |