| abstract |
The invention relates to pharmaceutical compositions for the delivery of therapeutic compounds to the respiratory system. More in particular, it deals with improved formulations of an antibiotic compound to prevent and treat bacterial infections of the respiratory system. The invention provides a solid pharmaceutical composition for the preparation of an aerosolizable liquid for inhalatin, comprising an effective amount of aztreonam and a basic excipient, wherein the ratio of aztreonam to the basic excipient is selected to yield a solution with a pH of about 3.5 to 5.5 when dissolved in water at an aztreonam concentration of about 30 to 200 mg/ml. Furthermore, the invention provides a pharmaceutical kit for the preparatin of an aerosolizable liquid for inhalation, comprising said solid pharmaceutical composition; and a method for the preparation of such a solid pharmaceutical composition. |