| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aea57db10fe6e572d4a54808447081e9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ee0b54f4d2991760c71d9fd631ac707f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d9f518481b88f0105b0066aa8974d4c6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5154
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5152 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0639
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0011 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0784
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02 |
| filingDate |
2003-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d9a1aa10eb5741594565d4044f3bdc2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7389f231c81fe41e82854a711f5c1648 |
| publicationDate |
2004-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2004050855-A2 |
| titleOfInvention |
Rapid one-step method for generation of antigen loaded dendritic cell vaccine from precursors |
| abstract |
A one-step method for producing antigen loaded antigen-presenting cells from monocytes ex vivo has been found which comprises contacting the monocytes with a composition comprising an activator such as TNF alpha preferably in combination with at least one growth factor such as GM-CSF and at least one soluble or particulate antigen. According to the methods of the present invention, antigen-loaded dendritic cell vaccines can be generated within as little as three (3) days. In another method of the present invention, antigen loaded antigen-presenting cells are produced from monocytes ex vivo by contacting the monocytes with TNF alpha and granulocyte-macrophage colony stimulating factor at one time point to form antigen-presenting cells and then contacting antigenpresenting cells with soluble or particulate antigenic material at a second time point to form antigen loaded antigen-presenting cells, wherein the antigen loaded antigen-presenting cells are produced in less than four days. The present invention also includes a vaccine which comprises monocyte-derived antigen loaded antigen-presenting cells, wherein the antigenpresenting cells are composed of two or more subsets selected from the group consisting of Langerhans cells with surface markers (CD 1 a+ CD207+); interstitial dendritic cells with surface markers (CD 1a+ CD207-); double negative dendritic cells with surface markers 20 (CD 1 a-CD 14-); and dendritic cells with surface markers (CD 14+ CD 1 a- CD209+). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012017033-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10980836-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8153425-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9694059-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006127150-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11013764-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3167898-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11248209-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11672874-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NO-345353-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE46152-E
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013167156-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008535493-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008515795-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8501470-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009040413-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11026973-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009038607-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7776324-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009040413-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11517589-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11628218-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11041023-B2 |
| priorityDate |
2002-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |