| abstract |
The present invention relates to a method for the solubilization of aceclofenac, wherein water-insoluble aceclofenac is added to a solvent mixture of polyethylene glycols, ethanolamines, basic amino acids such as arginine, Tween and glycerin, and also to a solubilized aceclofenac-containing liquid composition prepared therefrom. Furthermore, the present invention relates to a solubilized aceclofenac-containing soft capsule, which is prepared by mixing 1-30 parts by weight, based on the total weight of the contents of the soft capsule, of aceclofenac, 10-90 parts by weight of polyethylene glycols, 1-70 parts by weight of ethanolamines, 1-70 parts by weight of basic amino acids, 1-40 parts by weight of Tween and 2-15 parts by weight of glycerin at a certain temperature range so as to prepare a solubilized aceclofenac-containing liquid composition; and filling the solubilized aceclofenac-containing liquid composition in a gelatin soft capsule. |