| abstract |
Conjugate comprising an interleukin-10 (IL-10) polypeptide and a polymer. The IL-10 has at least one cyteine residue introduced (by substitution) in a position selected form 89 positions. The polymer (e.g. PEG) is attached to cysteine residue of the polypeptide. The conjugate exhibits immunosuppressive activity on T cells, B cells or antigen presenting cells. The conjugate should exhibit a reduced immunostimulatory activity compared to hIL-10. Use of said conjugate for treating inflammatory or autoimmune disease. |